In New York, Walsh was a member of the improvisational comedy troupe Burn Manhattan and the New York City Players theater ensemble.Launched via various social media channels, including Twitter, You Tube and select blogs, the Boyfriend webimercials have been viewed more than 200,000 times to date and were released by Walsh prior to her appearance on HSN to drive excitement and anticipation.She went on to portray Carol Nelson in HBO's The Mind of the Married Man television series, and played Norm Macdonald's romantic interest in the sitcom The Norm Show.Walsh also made a guest appearance on CSI: Crime Scene Investigation as Mimosa, a transsexual.Walsh appeared in the cult movie, Henry: Portrait of a Serial Killer, Part II.She had her first significant role in a major Hollywood production as Will Ferrell's character's wife in the family comedy, Kicking & Screaming, alongside Robert Duvall and Mike Ditka.
On September 18, 2008, Walsh was elected to serve on the SAG board for a three-year term.
She sometimes appeared in sketches on Late Night with Conan O'Brien.
She had a recurring role on Karen Sisco as Detective Marley Novak in 20.
However, she mentioned she'd be open to reprise her role in Grey's Anatomy for a few guest spots.
In 2013, Walsh appeared in Full Circle, a 10-episode ensemble drama series created by Neil La Bute and airing on Direc TV's Audience Network channel.