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    ) diagnosis of major depression, at least five depressive symptoms must have been present most of the time for two weeks and represent a change from previous functioning.At least one of the symptoms must be: In addition, there must be significant distress or impairment in functioning (such as at school, with friends or with the family).They are syndromes of persistent emotional, biological and psychological symptoms, accompanied by impaired social functioning.The most important of the depressive disorders is major depression.This makes it easy at a superficial level to decide what treatment we should use, and whether somebody is eligible for treatment at all.

    The American Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) defines a threshold of five symptoms.This review will discuss the concept of internalizing disorders.It will describe the two main types of internalizing disorder: depressive and anxiety disorders.It will discuss the aetiology of these disorders, and how modern scientific technology has been able to demonstrate differences and commonalities within this group of disorders.It will finish by discussing whether the concept of internalizing disorders (and the sub-classification of internalizing disorders) is helpful and valid.

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